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药物依赖严重程度量表可检测出药物过度使用人群:阿克什胡斯慢性头痛研究

The Severity of Dependence Scale detects people with medication overuse: the Akershus study of chronic headache.

作者信息

Grande R B, Aaseth K, Saltyte Benth J, Gulbrandsen P, Russell M B, Lundqvist C

机构信息

Head and Neck Research Group, Research Centre, Akershus University Hospital, Lørenskog 1478, Norway.

出版信息

J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):784-9. doi: 10.1136/jnnp.2008.168864. Epub 2009 Mar 11.

Abstract

OBJECTIVE

To evaluate the Severity of Dependence Scale (SDS) in people with primary chronic headache and analyse the pattern of medication overuse.

DESIGN

Cross sectional epidemiological survey. A posted questionnaire screened for chronic headache. Neurological residents interviewed those with self-reported chronic headache. The International Classification of Headache Disorders was used. Split file methodology was employed for data analysis.

SETTING

Akershus University Hospital, Oslo, Norway.

PARTICIPANTS

A random sample of 30,000 people, aged 30-44 years, from the general population of Akershus County, Norway. 405 people had primary chronic headache.

MAIN OUTCOME MEASURE

SDS score in those with and without medication overuse.

RESULTS

The screening questionnaire response rate was 71% and the participation rate of the interview 74%. Among 405 people with primary chronic headache, 95% had chronic tension-type headache, 4% had chronic migraine and <1% had other primary chronic headaches. Of 386 persons with chronic tension-type headache, 44% had medication overuse and 47% had co-occurrence of migraine. Simple analgesics, combination analgesics, triptans, ergotamine, opioids and a combination of acute medications were overused by 65%, 27%, 4%, <1%, 1% and 2% of people, respectively. The mean SDS score was significantly higher in those with than in those without medication overuse (5.6 vs 2.7; p<0.001).

CONCLUSION

The SDS questionnaire detects medication overuse and dependency-like behaviour in persons with primary chronic headache.

摘要

目的

评估原发性慢性头痛患者的药物依赖严重程度量表(SDS),并分析药物过度使用模式。

设计

横断面流行病学调查。通过邮寄问卷筛查慢性头痛患者。神经科住院医师对自我报告有慢性头痛的患者进行访谈。采用国际头痛疾病分类。数据分析采用拆分文件方法。

地点

挪威奥斯陆的阿克什胡斯大学医院。

参与者

从挪威阿克什胡斯郡普通人群中随机抽取30000名年龄在30 - 44岁之间的人。405人患有原发性慢性头痛。

主要观察指标

有或无药物过度使用患者的SDS评分。

结果

筛查问卷的回复率为71%,访谈的参与率为74%。在405例原发性慢性头痛患者中,95%患有慢性紧张型头痛,4%患有慢性偏头痛,<1%患有其他原发性慢性头痛。在386例慢性紧张型头痛患者中,44%存在药物过度使用,47%同时患有偏头痛。分别有65%、27%、4%、<1%、1%和2%的人过度使用单纯镇痛药、复合镇痛药、曲坦类药物、麦角胺、阿片类药物以及急性药物组合。有药物过度使用的患者的平均SDS评分显著高于无药物过度使用的患者(5.6对2.7;p<0.001)。

结论

SDS问卷可检测出原发性慢性头痛患者的药物过度使用和类似依赖行为。

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