Grande R B, Aaseth K, Saltyte Benth J, Gulbrandsen P, Russell M B, Lundqvist C
Head and Neck Research Group, Research Centre, Akershus University Hospital, Lørenskog 1478, Norway.
J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):784-9. doi: 10.1136/jnnp.2008.168864. Epub 2009 Mar 11.
To evaluate the Severity of Dependence Scale (SDS) in people with primary chronic headache and analyse the pattern of medication overuse.
Cross sectional epidemiological survey. A posted questionnaire screened for chronic headache. Neurological residents interviewed those with self-reported chronic headache. The International Classification of Headache Disorders was used. Split file methodology was employed for data analysis.
Akershus University Hospital, Oslo, Norway.
A random sample of 30,000 people, aged 30-44 years, from the general population of Akershus County, Norway. 405 people had primary chronic headache.
SDS score in those with and without medication overuse.
The screening questionnaire response rate was 71% and the participation rate of the interview 74%. Among 405 people with primary chronic headache, 95% had chronic tension-type headache, 4% had chronic migraine and <1% had other primary chronic headaches. Of 386 persons with chronic tension-type headache, 44% had medication overuse and 47% had co-occurrence of migraine. Simple analgesics, combination analgesics, triptans, ergotamine, opioids and a combination of acute medications were overused by 65%, 27%, 4%, <1%, 1% and 2% of people, respectively. The mean SDS score was significantly higher in those with than in those without medication overuse (5.6 vs 2.7; p<0.001).
The SDS questionnaire detects medication overuse and dependency-like behaviour in persons with primary chronic headache.
评估原发性慢性头痛患者的药物依赖严重程度量表(SDS),并分析药物过度使用模式。
横断面流行病学调查。通过邮寄问卷筛查慢性头痛患者。神经科住院医师对自我报告有慢性头痛的患者进行访谈。采用国际头痛疾病分类。数据分析采用拆分文件方法。
挪威奥斯陆的阿克什胡斯大学医院。
从挪威阿克什胡斯郡普通人群中随机抽取30000名年龄在30 - 44岁之间的人。405人患有原发性慢性头痛。
有或无药物过度使用患者的SDS评分。
筛查问卷的回复率为71%,访谈的参与率为74%。在405例原发性慢性头痛患者中,95%患有慢性紧张型头痛,4%患有慢性偏头痛,<1%患有其他原发性慢性头痛。在386例慢性紧张型头痛患者中,44%存在药物过度使用,47%同时患有偏头痛。分别有65%、27%、4%、<1%、1%和2%的人过度使用单纯镇痛药、复合镇痛药、曲坦类药物、麦角胺、阿片类药物以及急性药物组合。有药物过度使用的患者的平均SDS评分显著高于无药物过度使用的患者(5.6对2.7;p<0.001)。
SDS问卷可检测出原发性慢性头痛患者的药物过度使用和类似依赖行为。