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继发慢性头痛患者药物过度使用与依赖严重程度相关。阿克什胡斯慢性头痛研究。

The severity of dependence score correlates with medication overuse in persons with secondary chronic headaches. The Akershus study of chronic headache.

机构信息

Head and Neck Research Group, Research Centre, Akershus University Hospital, 1478 Lørenskog, Oslo, Norway Department of Neurology, Ullevaal University Hospital, 0407 Oslo, Norway HØKH, Research Centre, Akershus University Hospital, 1478 Lørenskog, Norway Faculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Norway.

出版信息

Pain. 2010 Mar;148(3):487-491. doi: 10.1016/j.pain.2009.12.010. Epub 2010 Jan 13.

Abstract

The objective was to compare the Severity of Dependence Scale (SDS) score and pattern of medication use in persons with secondary chronic headache (>or= 15 days/month for at least 3 months) in a cross-sectional epidemiological survey. A posted questionnaire screened for chronic headache. Neurological residents interviewed those with self-reported chronic headache. The International Classification of Headache Disorders was used. Split file methodology was employed for data analysis. People with secondary chronic headaches were identified in an age and gender stratified sample of 30,000 30-44 year olds from the general population. The interviews and examinations were conducted at the Akershus University Hospital, Oslo, Norway. The main outcome measure was the SDS score in those with and without medication overuse. Fifty-five (49%) of the 113 persons with secondary chronic headaches were found to have medication overuse. Fifty-eight percent overused simple analgesics and 31% overused combination analgesics. The SDS score was significantly higher among those with than without medication overuse (5.5 vs. 1.9). The sensitivity, specificity, positive and negative predictive values were 0.82, 0.82, 0.82 and 0.83, respectively. Thus the SDS score correlates with medication overuse, and a high SDS score suggests dependency-like behaviour in persons with secondary chronic headache. The use of SDS score in subjects with frequent pain episodes may contribute to the detection of medication overuse and better management of this group of patients.

摘要

目的在于比较继发性慢性头痛(每月持续>15 天且至少 3 个月)患者在横断面流行病学调查中的严重依赖量表(SDS)评分和药物使用模式。一份邮寄问卷对慢性头痛进行了筛选。神经科住院医师对自我报告有慢性头痛的患者进行了访谈。采用的是头痛疾病国际分类。采用拆分文件方法进行数据分析。在年龄和性别分层的 30000 名 30-44 岁普通人群样本中,确定了继发性慢性头痛患者。访谈和检查在挪威奥斯陆阿克什胡斯大学医院进行。主要观察指标为药物滥用患者和无药物滥用患者的 SDS 评分。在 113 名继发性慢性头痛患者中,发现 55 名(49%)患者存在药物滥用。58%的患者过度使用简单镇痛药,31%的患者过度使用复方镇痛药。与无药物滥用者相比,药物滥用者的 SDS 评分明显更高(5.5 比 1.9)。敏感性、特异性、阳性预测值和阴性预测值分别为 0.82、0.82、0.82 和 0.83。因此,SDS 评分与药物滥用相关,且高 SDS 评分提示继发性慢性头痛患者存在类似依赖的行为。在经常出现疼痛发作的患者中使用 SDS 评分可能有助于发现药物滥用,并更好地管理这组患者。

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