Bradford Porcia T, Devesa Susan S, Anderson William F, Toro Jorge R
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Blood. 2009 May 21;113(21):5064-73. doi: 10.1182/blood-2008-10-184168. Epub 2009 Mar 11.
There have been no prior large population-based studies focusing on cutaneous lymphomas (CL) in the United States. Using the Surveillance, Epidemiology and End Results (SEER) program data, we analyzed age-adjusted CL incidence rates (IRs) and survival rates by sex and race/ethnicity. There were 3884 CLs diagnosed during 2001-2005. Cutaneous T-cell lymphomas (CTCLs) accounted for 71% (age-adjusted incidence rate [IR] = 7.7/1 000 000 person-years), whereas cutaneous B-cell lymphomas(CBCLs) accounted for 29% (IR = 3.1/1 000 000 person-years). Males had a statistically significant higher IR of CL than females (14.0 vs 8.2/1 000 000 person-years, respectively; male-female IR ratio [M/F IRR] = 1.72; P < .001). CL IRs were highest among blacks and non-Hispanic whites (both 11.5/1 000 000 person-years), followed by Hispanic whites (7.9) and Asian/Pacific Islanders (7.1). The CTCL IR was highest among blacks (10.0/1 000 000 person-years), whereas the CBCL IR was highest among non-Hispanic whites (3.5). Over the past 25 years, the CL IR increased from 5.0/1 000 000 person-years during 1980-1982 to 14.3 during 2001-2003. During 2004-2005, the CL IR was 12.7. This recent apparent change could be incomplete case ascertainment or potential leveling off of IRs. CLs rates vary markedly by race and sex, supporting the notion that they represent distinct disease entities.
此前在美国尚未有基于大规模人群的皮肤淋巴瘤（CL）研究。利用监测、流行病学和最终结果（SEER）项目的数据，我们按性别和种族/族裔分析了年龄调整后的CL发病率（IR）和生存率。2001年至2005年期间共诊断出3884例CL。皮肤T细胞淋巴瘤（CTCL）占71%（年龄调整发病率[IR]=7.7/1000000人年），而皮肤B细胞淋巴瘤（CBCL）占29%（IR=3.1/1000000人年）。男性的CL发病率在统计学上显著高于女性（分别为14.0和8.2/1000000人年；男女发病率比[M/F IRR]=1.72；P<.001）。CL发病率在黑人和非西班牙裔白人中最高（均为11.5/1000000人年），其次是西班牙裔白人（7.9）和亚太岛民（7.1）。CTCL发病率在黑人中最高（10.0/1000000人年），而CBCL发病率在非西班牙裔白人中最高（3.5）。在过去25年中，CL发病率从1980 - 1982年的5.0/1000000人年增加到2001 - 2003年的14.3。在2004 - 2005年期间，CL发病率为12.7。这种近期明显的变化可能是病例确诊不完全或发病率潜在趋于平稳。CL发病率因种族和性别差异显著，支持了它们代表不同疾病实体的观点。
