Peters Wilbert H M, Lacko Martin, Te Morsche Rene H M, Voogd Adri C, Oude Ophuis Michael B, Manni Johannes J
Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Head Neck. 2009 Jul;31(7):938-43. doi: 10.1002/hed.21058.
Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of processes such as inflammation, cell proliferation, and angiogenesis, all relevant for cancer development. We investigated whether functional genetic polymorphisms in COX-2 may have a risk-modifying effect on head and neck carcinogenesis.
Blood from 431 white patients with oral, pharyngeal, or laryngeal carcinoma and 438 white healthy controls was investigated for the presence of 2 functional promoter region polymorphisms (-1195A-->G and -765G-->C) in COX-2.
Logistic regression analysis did not show differences in COX-2 genotype distributions between patients and controls. Also no differences were found when stratified according to tumor localization, sex, or tobacco consumption.
In contrast to earlier reports on the role of these COX-2 polymorphisms in mediating susceptibility to squamous esophageal carcinoma in a Chinese population, we could not demonstrate a risk-modifying effect in head and neck carcinogenesis in whites.
环氧化酶-2（COX-2）是一种参与前列腺素和血栓素合成的酶，而前列腺素和血栓素是炎症、细胞增殖和血管生成等过程的调节因子，所有这些过程都与癌症发展相关。我们研究了COX-2的功能性基因多态性是否对头颈部癌变有风险修饰作用。
对431例患有口腔、咽或喉癌的白人患者以及438例白人健康对照者的血液进行检测，以确定COX-2中2种功能性启动子区域多态性（-1195A→G和-765G→C）的存在情况。
逻辑回归分析未显示患者与对照者之间COX-2基因型分布存在差异。根据肿瘤定位、性别或烟草消费量进行分层时也未发现差异。
与之前关于这些COX-2多态性在中国人群中介导鳞状食管癌易感性作用的报道相反，我们未能证明其在白人头颈部癌变中有风险修饰作用。
