Hassan Ghada S, Merhi Yahye, Mourad Walid M
Laboratoire d'Immunologie Cellulaire et Moléculaire, Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, Montréal, QC H2X 1P1, Canada.
Trends Immunol. 2009 Apr;30(4):165-72. doi: 10.1016/j.it.2009.01.004. Epub 2009 Mar 11.
CD154, a member of the tumor necrosis factor-alpha family, has recently been implicated in the pathophysiology of vascular diseases. Indeed, blockade of CD154 by neutralizing antibodies or genetic disruption in mice prevents atherosclerosis and atherothrombosis. CD154 is believed to interact mainly via the CD40 receptor, however, it has also been found to bind with alphaIIbbeta3 integrin and so induces platelet activation. Moreover, we (and others) have recently identified the integrins alpha5beta1 and Mac-1 as novel CD154 receptors expressed on many cell types. Here, we illustrate the various functional features of these molecules, while describing the increasingly important role of CD40 in CD154-associated vascular pathologies such as atherosclerosis and atherothrombosis.
CD154是肿瘤坏死因子-α家族的一员，最近被认为与血管疾病的病理生理学有关。事实上，用中和抗体阻断CD154或在小鼠中进行基因破坏可预防动脉粥样硬化和动脉粥样血栓形成。人们认为CD154主要通过CD40受体相互作用，然而，也发现它与αIIbβ3整合素结合，从而诱导血小板活化。此外，我们（以及其他人）最近发现整合素α5β1和Mac-1是在许多细胞类型上表达的新型CD154受体。在这里，我们阐述了这些分子的各种功能特征，同时描述了CD40在与CD154相关的血管病变（如动脉粥样硬化和动脉粥样血栓形成）中日益重要的作用。
