Engel David, Seijkens Tom, Poggi Marjorie, Sanati Maryam, Thevissen Larissa, Beckers Linda, Wijnands Erwin, Lievens Dirk, Lutgens Esther
Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands.
Semin Immunol. 2009 Oct;21(5):308-12. doi: 10.1016/j.smim.2009.06.004. Epub 2009 Jul 17.
Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.
动脉粥样硬化是一种累及大动脉的慢性疾病，是大多数心血管事件的病因。在其发病机制中，免疫系统起着关键作用。通过共刺激分子介导的免疫细胞间相互作用实现的免疫反应，决定了动脉粥样硬化的严重程度。本综述将重点阐述最强大的共刺激二元组之一，即CD154（也称为CD40配体，CD40L）-CD40二元组在动脉粥样硬化中的作用。将讨论其细胞类型特异性作用、信号转导级联反应及其治疗潜力。
