Liversage R A, Rathbone M P, McLaughlin H M
J Exp Zool. 1977 Apr;200(1):169-75. doi: 10.1002/jez.1402000121.
Cyclic 3', 5'-guanosine monophosphate (cGMP) was measured at eight stages of forelimb regeneration in adult newts and compared with the cGMP levels of non-regenerating control limbs. There was a significant increase in cGMP content during dedifferentiation followed by a sharp decrease to minimal levels at the cone stage. A second smaller increase in cGMP occurred between the cone stage and mid-differentiation, followed by a decrease to relatively constant levels approaching control values as differentiation progressed. The changes in cGMP during dedifferentiation and during the period of highest cell proliferation indicate that cGMP may play a role in these processes. The smaller increases in cGMP levels during differentiation may reflect a reduced rate of cell division in the differentiating tissues.
在成年蝾螈前肢再生的八个阶段测量了环磷酸鸟苷（cGMP），并将其与未再生的对照肢体的cGMP水平进行比较。在去分化过程中，cGMP含量显著增加，随后在圆锥期急剧下降至最低水平。在圆锥期和分化中期之间，cGMP出现了第二次较小幅度的增加，随后随着分化的进行，cGMP下降至接近对照值的相对恒定水平。去分化过程中和细胞增殖最高时期的cGMP变化表明，cGMP可能在这些过程中发挥作用。分化过程中cGMP水平的较小幅度增加可能反映了分化组织中细胞分裂速率的降低。
