口腔白斑的棉签冷冻疗法。
Cotton-swab cryotherapy for oral leukoplakia.
作者信息
Yu Chuan-Hang, Chen Hsin-Ming, Chang Chia-Chuan, Hung Hsien-Yen, Hsiao Chuhsing Kate, Chiang Chun-Pin
机构信息
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
出版信息
Head Neck. 2009 Aug;31(8):983-8. doi: 10.1002/hed.21055.
BACKGROUND
Oral leukoplakia (OL) is a common oral precancerous lesion. Cotton-swab cryotherapy (CSC) is commonly used for treating skin lesions but is rarely used for treating OL lesions.
METHODS
Sixty OL lesions were treated by CSC once every 2 weeks until complete regression (CR) of the lesion had been achieved.
RESULTS
CR was achieved in all 60 OL lesions after an average of 6.3 treatments with cryotherapy. The number of CSC treatments required to achieve CR was significantly fewer for OL lesions on oral mucosal sites other than the tongue, those <2 cm2, those with epithelial dysplasia, and those with a surface keratin thickness of <55 microm. Multivariate analyses showed that only the location and area of the OL lesions were independent factors influencing the number of CSC treatments required to achieve CR.
CONCLUSION
For OL lesions with a mean surface area of < or = 1.8 cm2, CR can be achieved with fewer than 7 CSC treatments on average. CSC is a simple, safe, easy, conservative, and acceptable treatment modality for OL lesions.
背景
口腔白斑（OL）是一种常见的口腔癌前病变。棉拭子冷冻疗法（CSC）常用于治疗皮肤病变，但很少用于治疗OL病变。
方法
对60个OL病变每2周进行一次CSC治疗，直至病变完全消退（CR）。
结果
平均6.3次冷冻治疗后，所有60个OL病变均实现CR。对于舌以外口腔黏膜部位的OL病变、面积<2 cm2的病变、有上皮发育异常的病变以及表面角质层厚度<55微米的病变，实现CR所需的CSC治疗次数明显较少。多因素分析表明，只有OL病变的位置和面积是影响实现CR所需CSC治疗次数的独立因素。
结论
对于平均表面积≤1.8 cm2的OL病变，平均少于7次CSC治疗即可实现CR。CSC是一种用于OL病变的简单、安全、简便、保守且可接受的治疗方式。
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