Yoshimatsu H, Egawa M, Bray G A
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Am J Physiol. 1991 Oct;261(4 Pt 2):R875-81. doi: 10.1152/ajpregu.1991.261.4.R875.
Adrenal sympathetic nerve activity after microinfusion of 2-deoxy-D-glucose (2-DG) into various hypothalamic nuclei was investigated in anesthetized rats. Infusion of 2-DG into the ventrolateral portion of the lateral hypothalamic area (LHA) induced a large and long-lasting increase (greater than 60 min) in adrenal nerve activity. In contrast, infusion into the dorsal or medial portion of the LHA tended to produce a small decrease with a return to baseline within approximately 60 min after the end of the infusion. The direct administration of 2-DG into either the paraventricular nucleus or the dorsomedial hypothalamic nucleus produced a strong inhibition of adrenal nerve activity. Infusions into the ventromedial hypothalamic nucleus induced either a decrease of adrenal nerve activity or were without effect. These findings provide evidence that induction of glucoprivation in the hypothalamus with 2-DG can excite or inhibit adrenal nerve activity, depending on the hypothalamic region. These data also indicate that the ventrolateral portion of the LHA plays an important role in the regulation of adrenal catecholamine secretion in response to glucoprivic conditions in the central nervous system.
在麻醉大鼠中，研究了向各种下丘脑核团微量注入2-脱氧-D-葡萄糖（2-DG）后肾上腺交感神经活动的变化。向外侧下丘脑区（LHA）腹外侧部分注入2-DG可引起肾上腺神经活动大幅且持久的增加（超过60分钟）。相比之下，向LHA背侧或内侧部分注入2-DG往往会导致小幅下降，并在注入结束后约60分钟内恢复到基线水平。直接向室旁核或下丘脑背内侧核注入2-DG会强烈抑制肾上腺神经活动。向腹内侧下丘脑核注入2-DG会导致肾上腺神经活动降低或无影响。这些发现提供了证据，表明用2-DG在下丘脑诱导糖剥夺可根据下丘脑区域激发或抑制肾上腺神经活动。这些数据还表明，LHA腹外侧部分在中枢神经系统糖剥夺条件下肾上腺儿茶酚胺分泌的调节中起重要作用。
