Yoshimatsu H, Oomura Y, Katafuchi T, Niijima A
Am J Physiol. 1987 Sep;253(3 Pt 2):R418-24. doi: 10.1152/ajpregu.1987.253.3.R418.
Activity changes of efferent adrenal sympathetic nerves in response to bilateral manipulations of the hypothalamus, partly after intra-third cerebroventricular injection of 2-deoxy-D-glucose (2-DG) were investigated in anesthetized rats. Stimulation of the middle part of the lateral hypothalamic area (LHAm) increased adrenal nerve activity, whereas lesion caused rapid and remarkable decrease. Stimulation of the anterior part of the LHA (LHAa) tended to decrease the activity, and lesion produced either rapid decrease or late moderate increase. Stimulation of the ventromedial hypothalamic nucleus (VMH) did not affect the nerve activity, but lesion increased it gradually and then remarkably. Cerebroventricular infusion of 2-DG caused remarkable increase in activity that was suppressed by LHAm lesion. Subsequent infusion of 2-DG during the period of suppressed activity was no longer effective. The increased firing rate after 2-DG was suppressed by stimulation of the VMH, whereas lesion caused no change. These findings indicate that the central regulation of adrenal nerve activity is connected with individual hypothalamic regions and consequently depends on the degree and mode of activation of the sympathoadrenal system.
在麻醉大鼠中，研究了下丘脑双侧操作（部分是在第三脑室内注射2-脱氧-D-葡萄糖（2-DG）后）引起的肾上腺传出交感神经的活动变化。刺激下丘脑外侧区中部（LHAm）可增加肾上腺神经活动，而损毁则导致迅速且显著的降低。刺激下丘脑外侧区前部（LHAa）倾向于降低活动，而损毁则导致迅速降低或后期适度增加。刺激腹内侧下丘脑核（VMH）不影响神经活动，但损毁会使其逐渐增加，然后显著增加。脑室内注入2-DG导致活动显著增加，而LHAm损毁可抑制该增加。在活动受到抑制期间随后注入2-DG不再有效。2-DG后增加的放电频率可被VMH刺激所抑制，而损毁则无变化。这些发现表明，肾上腺神经活动的中枢调节与各个下丘脑区域相关，因此取决于交感肾上腺系统的激活程度和方式。
