通过钯催化的串联C-H活化/双环化反应实现苯并[a]蒽衍生物的高度区域选择性合成。
Highly regioselective synthesis of benz[a]anthracene derivatives via a Pd-catalyzed tandem C-H activation/biscyclization reaction.
作者信息
Ren Zhi-Hui, Guan Zheng-Hui, Liang Yong-Min
机构信息
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
出版信息
J Org Chem. 2009 Apr 17;74(8):3145-7. doi: 10.1021/jo802712n.
PMID:19284714
Abstract
A palladium-catalyzed tandem C-H activation/biscyclization reaction of propargylic carbonates with terminal alkynes was determined, which allowed the tetracyclic benz[a]anthracene framework to be constructed with high regioselectivity. A possible mechanism for this tandem C-H activation/biscyclization process was discussed.
摘要
确定了一种钯催化的碳酸炔丙酯与端炔的串联C-H活化/双环化反应，该反应能够以高区域选择性构建四环苯并[a]蒽骨架。讨论了这种串联C-H活化/双环化过程的可能机理。
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