高区域选择性钯催化吲哚嗪和乙烯芳烃通过 C-H 键断裂的氧化偶联反应。
Highly regioselective palladium-catalyzed oxidative coupling of indolizines and vinylarenes via C-H bond cleavage.
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
出版信息
Org Lett. 2009 Dec 17;11(24):5606-9. doi: 10.1021/ol902315w.
PMID:19924879
Abstract
A highly regioselective oxidative coupling reaction between indolizines and vinylarenes has been accomplished in the presence of palladium catalysts to give only the branched alpha-product in high efficiency. The regioselectivity is promoted significantly by bidentate nitrogen ligands.
摘要
在钯催化剂的存在下，成功地实现了吲哚嗪和乙烯芳烃之间的高区域选择性氧化偶联反应，以高效率仅得到支化的α-产物。双齿氮配体显著促进了区域选择性。
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