一项关于结直肠癌中静脉侵犯的前瞻性临床病理研究。

A prospective clinicopathologic study of venous invasion in colorectal cancer.

作者信息

Shirouzu K, Isomoto H, Kakegawa T, Morimatsu M

机构信息

First Department of Surgery, Kurume University School of Medicine, Kurumeshi, Japan.

出版信息

Am J Surg. 1991 Sep;162(3):216-22. doi: 10.1016/0002-9610(91)90073-m.

DOI:10.1016/0002-9610(91)90073-m

PMID:1928581

Abstract

We performed a long-term prospective study on venous invasion of colorectal cancer. The degree of venous invasion was divided into four stages (V0 through V3). Venous invasion was classified into three types by location (Vx, Vy, and Vz). Hepatic metastasis occurred in 27%, 33%, and 20% of patients with V2, V3, and Vz tumors, respectively. Local recurrence occurred in 33% and 15% of the V3 and Vz groups, respectively. However, there were no significant differences among the groups in terms of the rate of pulmonary metastasis. The 6-year survival rate for Dukes' stage B tumors was 94%, 88%, and 74% in the V0, V1, and V2 groups, respectively. There was a significant difference in the survival rate between patients with V0 tumors and V2 and V3 tumors. However, no significant difference was noted in the location. In Dukes' stage C tumors, on the other hand, the survival rate was 77%, 56%, and 44% in the V1, V2, and V3 groups, respectively. Also, it was 85%, 73%, and 45% in Vx, Vy, and Vz cases, respectively. Significant differences were noted between V1 and V3 (or V2), and between Vz and Vx (or Vy). It appears that the degree and location of venous invasion influence not only hepatic metastasis, local recurrence, and survival rates but also have prognostic value.

摘要

我们对结直肠癌的静脉侵犯进行了一项长期前瞻性研究。静脉侵犯程度分为四个阶段（V0至V3）。静脉侵犯按位置分为三种类型（Vx、Vy和Vz）。V2、V3和Vz肿瘤患者的肝转移发生率分别为27%、33%和20%。V3组和Vz组的局部复发率分别为33%和15%。然而，各组之间在肺转移率方面没有显著差异。Dukes B期肿瘤在V0、V1和V2组中的6年生存率分别为94%、88%和74%。V0肿瘤患者与V2和V3肿瘤患者的生存率存在显著差异。然而，在位置方面未发现显著差异。另一方面，在Dukes C期肿瘤中，V1、V2和V3组的生存率分别为77%、56%和44%。Vx、Vy和Vz病例的生存率分别为85%、73%和45%。V1与V3（或V2）之间以及Vz与Vx（或Vy）之间存在显著差异。似乎静脉侵犯的程度和位置不仅影响肝转移、局部复发和生存率，而且具有预后价值。