Beljaards R C, Meijer C J, Scheffer E, van der Valk P, Willemze R
Department of Dermatology, Free University Hospital, Amsterdam, The Netherlands.
Am J Dermatopathol. 1991 Aug;13(4):342-9. doi: 10.1097/00000372-199108000-00004.
We studied a large panel of monoclonal antibodies reactive on routinely processed paraffin-embedded tissue to determine their sensitivity and specificity in the diagnosis of 35 primary cutaneous large cell lymphomas of B- (n = 14) and T-cell origin (n = 21). The findings show that differentiation between clinically relevant subgroups can be obtained by a small panel of antibodies including L26, MB2, LN1, MT1, UCHL1, and Ber-H2. Pitfalls in the use of the reagents are discussed.
我们研究了一大组对常规处理的石蜡包埋组织有反应的单克隆抗体，以确定它们在诊断35例B细胞起源（n = 14）和T细胞起源（n = 21）的原发性皮肤大细胞淋巴瘤中的敏感性和特异性。研究结果表明，通过一小组抗体，包括L26、MB2、LN1、MT1、UCHL1和Ber-H2，可以区分临床相关亚组。文中还讨论了这些试剂使用中的陷阱。
