Short S M, Aun C S
Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories.
Anaesthesia. 1991 Sep;46(9):783-5. doi: 10.1111/j.1365-2044.1991.tb09781.x.
The haemodynamic effects of induction of anaesthesia with propofol in children were studied. Two hundred and sixteen children (ASA 1) were randomly allocated to receive one of six different doses of propofol, from 1.6 mg/kg to 2.6 mg/kg, in 0.2 mg/kg increments. Noninvasive measurement of blood pressure showed that mean arterial pressure was reduced by approximately 15% after 1 minute, and by 30% after 5 minutes. The reduction in pulse rate over a 5-minute period was approximately 17%. These changes were similar in each group, regardless of the dose administered. The propofol was mixed with lignocaine, 0.5 mg/ml, and the incidence of pain on injection into a vein on the dorsum of the hand was 24%. We conclude that, within the dose range of our study, the haemodynamic disturbance after induction of anaesthesia with propofol in children is not dose related.
研究了丙泊酚用于小儿麻醉诱导的血流动力学效应。216例（ASA 1级）小儿被随机分配接受六种不同剂量丙泊酚中的一种，剂量范围为1.6mg/kg至2.6mg/kg，以0.2mg/kg递增。无创血压测量显示，1分钟后平均动脉压降低约15%，5分钟后降低30%。5分钟内脉搏率降低约17%。无论给药剂量如何，每组的这些变化相似。丙泊酚与0.5mg/ml的利多卡因混合，手背静脉注射时的疼痛发生率为24%。我们得出结论，在本研究的剂量范围内，小儿丙泊酚麻醉诱导后的血流动力学紊乱与剂量无关。
