Teiblum Sandra, Thygesen Lau Caspar, Johansen Christoffer
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
Pancreas. 2009 May;38(4):374-8. doi: 10.1097/MPA.0b013e31819b71ae.
We report the incidence rates of pancreatic cancer in Denmark during 61 years of data registration, from 1943 to 2003.
On the basis of reports in the nationwide, population-based Danish Cancer Registry, we calculated age-standardized, period-specific incidence rates of pancreatic cancer.
A total of 32,654 incident cases of pancreatic cancer were evaluated (male-female ratio, 1.4). The age-standardized incidence rate of pancreatic cancer increased steadily in the beginning of the study period from 3.75/100,000 person-years in 1943 to 1947 to the maximum of 9.96/100,000 person-years in 1968 to 1972 among men and from 2.95 in 1943 to 1947 to the maximum of 7.04 in 1978 to 1982 among women. The incidence rates declined between 1968 to 1972 and 1988 to 1992 for men and between 1978 to 1982 and 2003 for women. Most tumors were located in the exocrine pancreas, and most were adenocarcinomas. More than 40% were located in the head of the pancreas; 14% were localized, 21% were regionally spread, and 36% were metastatic at the time of diagnosis. During the period 1978 to 2003, the percentages of histologically or cytologically verified adenocarcinomas remained relatively steady, approximately 30%.
The incidence rate of pancreatic cancer increased at the beginning of the 61 years of registration and declined slightly thereafter.
我们报告了1943年至2003年61年数据登记期间丹麦胰腺癌的发病率。
基于全国性、以人群为基础的丹麦癌症登记处的报告，我们计算了胰腺癌的年龄标准化、特定时期发病率。
共评估了32654例胰腺癌发病病例（男女比例为1.4）。在研究期开始时，胰腺癌的年龄标准化发病率稳步上升，男性从1943年至1947年的3.75/10万/人年升至1968年至1972年的最高值9.96/10万/人年，女性从1943年至1947年的2.95升至1978年至1982年的最高值7.04。男性在1968年至1972年与1988年至1992年之间发病率下降，女性在1978年至1982年与2003年之间发病率下降。大多数肿瘤位于外分泌胰腺，且大多数为腺癌。超过40%位于胰头；诊断时14%为局限性，21%为区域扩散，36%为转移性。在1978年至2003年期间，经组织学或细胞学证实的腺癌百分比保持相对稳定，约为30%。
在61年登记期开始时胰腺癌发病率上升，此后略有下降。
