Howitz M F, Johansen C, Tos M, Charabi S, Olsen J H
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Am J Otol. 2000 Sep;21(5):690-4.
To establish the incidence rate of vestibular schwannomas (VS) (acoustic neuromas) in Denmark.
The worldwide incidence rates of VS vary from 1 to 20 cases per million population per year.
The nationwide and population-based age-specific, sex-specific, and calendar year-specific incidence rates of VS in Denmark between 1977 and 1995 are presented. Information on cases of VS was obtained from the Danish Cancer Registry and a clinical database situated at the University Hospital of Gentofte. A total of 795 cases were reported during the period of the study.
The incidence rate increased from 5 cases per million population per year in 1977-1981 to 10 cases in 1992-1995; the increase was from 5 to 11 cases among women and 5 to 9 cases among men. The age-specific incidence rates show that VS is rarely diagnosed in persons under 30, but the incidence rate appears to increase among women after menopause.
The overall incidence rate of VS increased linearly during the study period, probably owing to the introduction of more precise diagnostic procedures, increased awareness among physicians and patients of the symptoms of VS, improved registration of benign tumors in Denmark, and the use of data from two sources.
确定丹麦前庭神经鞘瘤（VS）（听神经瘤）的发病率。
全球范围内VS的发病率为每年每百万人口1至20例。
呈现了1977年至1995年丹麦全国范围内基于人群的按年龄、性别和历年划分的VS发病率。VS病例信息来自丹麦癌症登记处和根措夫特大学医院的一个临床数据库。研究期间共报告了795例病例。
发病率从1977 - 1981年的每年每百万人口5例增至1992 - 1995年的10例；女性从5例增至11例，男性从5例增至9例。按年龄划分的发病率显示，30岁以下人群很少诊断出VS，但绝经后女性的发病率似乎有所上升。
在研究期间，VS的总体发病率呈线性上升，这可能归因于采用了更精确的诊断程序、医生和患者对VS症状的认识提高、丹麦良性肿瘤登记工作的改进以及使用了来自两个来源的数据。
