Pompy L, Karlin A, Capuano C M, Cottrell J E, Hartung J
Department of Anesthesiology, SUNY Health Science Center, Brooklyn 11203.
Anesthesiology. 1991 Oct;75(4):669-72. doi: 10.1097/00000542-199110000-00018.
It has been hypothesized recently that succinylcholine-associated increases in intracranial pressure (ICP) are caused by the paraben preservatives contained in multidose vials. We tested that hypothesis in a standard feline model to determine the effects on ICP of equal-volume injections of preservative-free succinylcholine, succinylcholine with preservatives from multi-dose vials that contain both propylparaben and methylparaben, these preservatives alone at five times the dose contained in the succinylcholine, and normal saline. The preservatives alone increased ICP by 0.08 +/- 0.08 mmHg (+/- standard error; not significant). Normal saline had no effect on ICP. Preservative-free succinylcholine and succinylcholine with preservatives increased ICP by 4.2 +/- 0.10 and 3.8 +/- 0.07 mmHg respectively (P less than 0.01 compared to the preservatives alone and normal saline). The 99% upper confidence limit for the increase in ICP induced by the preservatives alone was 0.42 mmHg. This result suggests that parabens do not cause or substantially augment the ICP increase associated with succinylcholine administration.
最近有人提出假说，认为琥珀酰胆碱相关的颅内压（ICP）升高是由多剂量瓶中含有的对羟基苯甲酸酯防腐剂引起的。我们在标准猫模型中对该假说进行了测试，以确定等体积注射无防腐剂的琥珀酰胆碱、含有对羟基苯甲酸丙酯和对羟基苯甲酸甲酯的多剂量瓶中含防腐剂的琥珀酰胆碱、这些防腐剂单独使用时剂量为琥珀酰胆碱中所含剂量的五倍以及生理盐水对ICP的影响。单独使用这些防腐剂使ICP升高了0.08±0.08 mmHg（±标准误差；无显著性差异）。生理盐水对ICP无影响。无防腐剂的琥珀酰胆碱和含防腐剂的琥珀酰胆碱分别使ICP升高了4.2±0.10 mmHg和3.8±0.07 mmHg（与单独使用防腐剂和生理盐水相比，P＜0.01）。单独使用防腐剂引起的ICP升高的99%置信上限为0.42 mmHg。该结果表明，对羟基苯甲酸酯不会导致或显著增加与琥珀酰胆碱给药相关的ICP升高。
