Gelb A W, Gignac E, Manninen P H, Farrar J K, Lee D H
Department of Anaesthesia, University Hospital, London, Ontario, Canada.
Can J Anaesth. 1992 Sep;39(7):691-4. doi: 10.1007/BF03008232.
In vitro studies suggest that the preservatives methylparaben and propylparaben included in some multidose vials of succinylcholine are the cerebral vasodilators responsible for the increases in intracranial pressure (ICP) documented after succinylcholine administration. To test this hypothesis, we measured cerebral blood flow (CBF) and cerebral blood flow velocity (CBFV) with inhaled 133Xenon and transcranial Doppler respectively in healthy humans before and after the intravenous administration of methylparaben and propylparaben. We found no change in either CBF or CBFV after the paraben injections and therefore conclude that it is unlikely that the rise in ICP seen with succinylcholine is caused by cerebral arterial vasodilatation from the preservatives methylparaben and propylparaben.
体外研究表明，某些琥珀酰胆碱多剂量小瓶中含有的防腐剂对羟基苯甲酸甲酯和对羟基苯甲酸丙酯是脑血管扩张剂，它们导致了琥珀酰胆碱给药后记录到的颅内压（ICP）升高。为了验证这一假设，我们分别在健康人体静脉注射对羟基苯甲酸甲酯和对羟基苯甲酸丙酯之前和之后，用吸入式133氙和经颅多普勒测量了脑血流量（CBF）和脑血流速度（CBFV）。对羟基苯甲酸酯注射后，我们发现CBF和CBFV均无变化，因此得出结论，琥珀酰胆碱引起的ICP升高不太可能是由防腐剂对羟基苯甲酸甲酯和对羟基苯甲酸丙酯导致的脑动脉血管扩张引起的。
