Silva Denise Rossato, Gazzana Marcelo Basso, John Angela Beatriz, Siqueira Débora Rodrigues, Maia Ana Luiza Silva, Barreto Sérgio Saldanha Menna
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.
J Bras Pneumol. 2009 Feb;35(2):179-85. doi: 10.1590/s1806-37132009000200012.
Recent studies have suggested an association between pulmonary arterial hypertension (PAH) and thyroid diseases (hypothyroidism and hyperthyroidism). This combination has a good prognosis, because the increase in the pulmonary artery pressure is usually slight and reverses after the treatment of the thyroid disease. Although the exact mechanism involved in the pathogenesis of this combination has not yet been established, it has been hypothesized that thyroid hormones and autoimmunity have a direct influence. Due to the high prevalence of thyroid disease in patients with PAH, thyroid function tests should be considered in the investigation of every patient with PAH. In this review, we describe the prevalence of PAH in patients with thyroid diseases and the prevalence of thyroid disease in patients with PAH, as well as addressing the principal effects that thyroid diseases have on the respiratory system. In addition, we report the treatment effects in patients with these diseases.
最近的研究表明，肺动脉高压（PAH）与甲状腺疾病（甲状腺功能减退和甲状腺功能亢进）之间存在关联。这种组合预后良好，因为肺动脉压力的升高通常较轻，且在甲状腺疾病治疗后会逆转。尽管这种组合发病机制的确切机制尚未明确，但据推测甲状腺激素和自身免疫有直接影响。由于PAH患者中甲状腺疾病的患病率较高，因此在对每位PAH患者进行检查时都应考虑进行甲状腺功能测试。在本综述中，我们描述了甲状腺疾病患者中PAH的患病率以及PAH患者中甲状腺疾病的患病率，并阐述了甲状腺疾病对呼吸系统的主要影响。此外，我们报告了这些疾病患者的治疗效果。
