Cohen S M, Mathews T
Department of Medicine, Wright State University School of Medicine, Dayton, Ohio.
Angiology. 1991 Sep;42(9):741-6. doi: 10.1177/000331979104200908.
Painful diabetic distal sensory neuropathy is a disabling and common complication of diabetes mellitus. There is evidence that microvascular changes resulting in ischemia to the vasa nervorum may contribute to this problem. Pentoxifylline has been shown to improve circulation through partially occluded peripheral vessels and has been postulated to be of potential benefit. Forty adult type II diabetics were enrolled in a double-blind, placebo-controlled study utilizing pentoxifylline for six months. Visual analog scores, nerve conduction studies, and physical examinations were used to evaluate response to treatment. At the end of the six-month trial, there was no significant difference in the patients' pain between the pentoxifylline- and placebo-treated groups. The authors conclude that pentoxifylline is not useful in the treatment of painful distal diabetic neuropathy.
疼痛性糖尿病远端感觉神经病变是糖尿病常见的致残并发症。有证据表明，导致神经血管缺血的微血管变化可能是造成这一问题的原因。已证实己酮可可碱可改善通过部分阻塞的外周血管的血液循环，并推测其可能具有潜在益处。40名成年II型糖尿病患者参加了一项为期6个月的双盲、安慰剂对照研究，使用己酮可可碱进行治疗。采用视觉模拟评分、神经传导研究和体格检查来评估治疗反应。在为期6个月的试验结束时，己酮可可碱治疗组和安慰剂治疗组患者的疼痛程度没有显著差异。作者得出结论，己酮可可碱对治疗疼痛性糖尿病远端神经病变无效。
