铁催化脂肪族与芳香族有机锌试剂之间的氧化杂偶联反应：一种实现官能化芳基-烷基交叉偶联反应的新途径。

Iron-catalyzed oxidative heterocoupling between aliphatic and aromatic organozinc reagents: a novel pathway for functionalized aryl-alkyl cross-coupling reactions.

作者信息

Cahiez Gérard, Foulgoc Laura, Moyeux Alban

机构信息

Department of Chemistry (FRE 3043), CNRS-Université de Paris 13, 74 Rue Marcel Cachin, 93017 Bobigny, France.

出版信息

Angew Chem Int Ed Engl. 2009;48(16):2969-72. doi: 10.1002/anie.200900175.

DOI:10.1002/anie.200900175

PMID:19288504

Abstract

Aryl-alkyl cross-coupling products are obtained by the iron-catalyzed oxidative heterocoupling of organozinc reagents under mild conditions. This novel reaction pathway is versatile, allowing for the use of primary and secondary aliphatic diorganozinc reagents as coupling partners as well as tolerating functionalized aryl- and alkylzinc reagents.

摘要

芳基 - 烷基交叉偶联产物是通过在温和条件下铁催化的有机锌试剂的氧化杂偶联反应得到的。这种新型反应途径具有通用性，允许使用伯和仲脂肪族二有机锌试剂作为偶联伙伴，并且能够耐受官能化的芳基锌试剂和烷基锌试剂。