Rose S R, Gorman R L, Oderda G M, Klein-Schwartz W, Watson W A
Carolinas Poison Center, Carolinas Medical Center, Charlotte, North Carolina 28232-2861.
Ann Emerg Med. 1991 Oct;20(10):1064-8. doi: 10.1016/s0196-0644(05)81353-8.
To determine the absorption rate of a supratherapeutic dose of acetaminophen elixir and compare the effect of activated charcoal (AC) given at different time intervals on preventing acetaminophen absorption.
Randomized, nonblinded, crossover controlled study.
A certified regional poison control center.
Ten healthy, adult male volunteers from 21 to 39 years old.
Each subject received 5 g acetaminophen (elixir) on four occasions: a control phase plus 30 g of AC administered 15, 30, or 120 minutes after acetaminophen. Serum acetaminophen levels were obtained during the control phase only, and 24-hour urine collections were obtained during all four phases.
The highest serum acetaminophen levels were measured 1.4 +/- 0.52 hours after ingestion, and absorption was 97% complete by a mean of 2.05 hours. The administration of AC at 15, 30, and 120 minutes after acetaminophen reduced urinary recovery of acetaminophen and metabolites by 48%, 44%, and 33%, respectively.
AC significantly reduces urinary recovery but not absorption of acetaminophen when administered two hours after acetaminophen elixir.
确定超治疗剂量对乙酰氨基酚酏剂的吸收率，并比较在不同时间间隔给予活性炭（AC）对预防对乙酰氨基酚吸收的效果。
随机、非盲、交叉对照研究。
一家经认证的地区毒物控制中心。
10名年龄在21至39岁之间的健康成年男性志愿者。
每位受试者分四次服用5克对乙酰氨基酚（酏剂）：一个对照阶段，以及在服用对乙酰氨基酚后15、30或120分钟给予30克AC。仅在对照阶段测定血清对乙酰氨基酚水平，在所有四个阶段均收集24小时尿液。
摄入后1.4±0.52小时测得血清对乙酰氨基酚水平最高，平均2.05小时时吸收完成97%。在服用对乙酰氨基酚后15、30和120分钟给予AC，分别使对乙酰氨基酚及其代谢产物的尿回收率降低48%、44%和33%。
在服用对乙酰氨基酚酏剂两小时后给予AC，可显著降低对乙酰氨基酚的尿回收率，但不影响其吸收。
