Clark R F, Selden B S, Curry S C
Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona.
Ann Emerg Med. 1991 Oct;20(10):1073-7. doi: 10.1016/s0196-0644(05)81355-1.
To examine the efficacy of digoxin-specific Fab fragments (dsFab) in the treatment of experimentally induced Nerium oleander cardiac glycoside toxicity in a dog model.
A nonblined, placebo-controlled experiment.
Ten adult greyhound dogs of either sex divided into treatment and control groups of five dogs each.
A tincture of oleander was prepared and administered intravenously to each animal. After the onset of cardiotoxicity, the treatment group received 60 mg/kg dsFab IV.
All dogs exhibited dysrhythmias meeting our criteria for cardiac glycoside cardiotoxicity within 27 minutes of beginning the infusion. Three of five control dogs had lethal dysrhythmias during the three-hour observation period. The remaining two control dogs exhibited dysrhythmias throughout the three-hour experiment. All five of the dsFab-treated dogs survived and converted to normal sinus rhythm within eight minutes of dsFab infusion. Three treatment animals reverted back to nonlethal and hemodynamically stable dysrhythmias after a mean of 107 minutes.
Large doses of dsFab are efficacious in the treatment of dysrhythmias in this canine model of N oleander cardiac glycoside poisoning.
在犬模型中检验地高辛特异性Fab片段（dsFab）治疗实验性诱导的夹竹桃强心苷中毒的疗效。
一项非盲、安慰剂对照实验。
10只成年灰狗，雌雄不限，分为治疗组和对照组，每组5只。
制备夹竹桃酊剂并静脉注射给每只动物。出现心脏毒性后，治疗组静脉注射60mg/kg的dsFab。
所有犬在开始输注后27分钟内均出现符合我们强心苷心脏毒性标准的心律失常。5只对照犬中有3只在3小时观察期内出现致命性心律失常。其余2只对照犬在整个3小时实验中均出现心律失常。所有5只接受dsFab治疗的犬均存活，并在dsFab输注后8分钟内转为正常窦性心律。3只治疗动物在平均107分钟后恢复为非致命性且血流动力学稳定的心律失常。
大剂量dsFab对该夹竹桃强心苷中毒犬模型的心律失常治疗有效。
