Page C, Murtaugh R J
Department of Internal Medicine, VCA All-Care Animal Referral Center, 18440 Amistad Street, Fountain Valley, CA, 92708, USA,
J Med Toxicol. 2015 Mar;11(1):141-3. doi: 10.1007/s13181-014-0436-x.
Oleander poisoning typically results in cardiac arrhythmias, hyperkalemia, and gastrointestinal irritation, and can be fatal. Oleander extracts have also been studied experimentally as hypoglycemic agents. Here, we describe a dog with confirmed oleander toxicosis presenting with classical symptoms and also hypoglycemia. After excluding other likely causes of hypoglycemia, the finding was attributed to oleander toxicosis, which has not been previously reported in dogs. A 7-year-old female spayed Maltese was presented to the emergency service after ingesting oleander leaves. Toxicosis was confirmed by measurement of digoxin using a competitive binding immunoassay, patient level 0.7 ng/mL (0.9 nmol/L) 24-h post-ingestion. Clinical symptoms included vomiting, cardiac arrhythmia, mild hyperkalemia, and hypoglycemia. Treatment was successful with aggressive supportive care, and the dog was discharged from the hospital after 48 h and made a full recovery. This case reviews the presentation and treatment of oleander toxicity but also highlights possible effects of oleander on blood sugar in dogs. Hypoglycemia in this dog, attributed to oleander poisoning, is interesting as it supports experimental research into hypoglycemic properties of oleander extracts.
夹竹桃中毒通常会导致心律失常、高钾血症和胃肠道刺激，甚至可能致命。夹竹桃提取物也作为降血糖药物进行过实验研究。在此，我们描述一只确诊为夹竹桃中毒的犬，它出现了典型症状以及低血糖。在排除了其他可能导致低血糖的原因后，这一发现归因于夹竹桃中毒，而此前在犬类中尚未有过此类报道。一只7岁已绝育的雌性马尔济斯犬在误食夹竹桃叶子后被送往急诊。通过竞争性结合免疫测定法测量地高辛，确认中毒，摄入后24小时患者水平为0.7 ng/mL（0.9 nmol/L）。临床症状包括呕吐、心律失常、轻度高钾血症和低血糖。积极的支持性治疗取得了成功，这只犬在48小时后出院并完全康复。本病例回顾了夹竹桃中毒的表现和治疗，但也突出了夹竹桃对犬血糖可能产生的影响。这只犬因夹竹桃中毒导致低血糖，这很有意思，因为它支持了对夹竹桃提取物降血糖特性的实验研究。
