DeBord J R, Marshall W H, Wyffels P L, Marshall J S, Humphrey P
Department of Surgery, University of Illinois, College of Medicine, Peoria.
Am Surg. 1991 Oct;57(10):627-32; discussion 632-3.
Three hundred twenty-four carotid endarterectomies (CEAs) were performed on 303 patients over 5 years. Sixty per cent of the patients were symptomatic with completed stroke (36.4%), amaurosis fugax (35.4%) or transient ischemic attack (TIA) (50.5%). Some patients had multiple symptoms. Perioperative stroke occurred in four patients (1.2%) and 30-day mortality in five (1.5%). The combined stroke-mortality rate was 2.8 per cent. Other postoperative complications included TIA (1.9%), cranial nerve injury (3.1%), wound hematoma (6.5%), and hypertensive reperfusion syndrome (9.6%). Ten early reoperations were performed for wound hematoma (7) or technical problems (3). Follow-up of 284 CEAs (88%) at a means of 31 months revealed 33 late deaths, with two due to stroke. Late strokes occurred in 11 patients (3.9%). Five late strokes were ipsilateral (1.8%) and six were contralateral (2.1%) to the operated carotid artery. Ninety-seven carotid arteries were evaluated by duplex ultrasound scanning at a mean postoperative interval of 27.2 months. Ninety-two per cent had 0-30 per cent restenosis, 5 per cent had 40 per cent to 60 per cent restenosis and 3 per cent had 70 per cent or greater restenosis. The authors conclude that CEA can be performed with acceptable morbidity and mortality rates and that it is a durable operation that reduces the risk of late stroke.
在5年时间里,对303例患者实施了324例颈动脉内膜切除术(CEA)。60%的患者有症状,表现为完全性卒中(36.4%)、一过性黑矇(35.4%)或短暂性脑缺血发作(TIA)(50.5%)。一些患者有多种症状。围手术期有4例患者发生卒中(1.2%),5例患者在30天内死亡(1.5%)。卒中 - 死亡率合计为2.8%。其他术后并发症包括TIA(1.9%)、脑神经损伤(3.1%)、伤口血肿(6.5%)和高血压再灌注综合征(9.6%)。因伤口血肿(7例)或技术问题(3例)进行了10例早期再次手术。对284例(88%)CEA患者平均随访31个月,发现33例晚期死亡,其中2例死于卒中。11例患者发生晚期卒中(3.9%)。5例晚期卒中发生在手术侧颈动脉同侧(1.8%),6例发生在对侧(2.1%)。在术后平均27.2个月时,对97条颈动脉进行了双功超声扫描评估。92%的患者有0 - 30%的再狭窄,5%的患者有40% - 60%的再狭窄,3%的患者有70%或更高程度的再狭窄。作者得出结论,CEA手术的发病率和死亡率可接受,并且是一种持久的手术,可降低晚期卒中风险。