有机阴离子转运多肽1A2的药物遗传学
Pharmacogenetics of the organic anion transporting polypeptide 1A2.
作者信息
Franke Ryan M, Scherkenbach Lisa A, Sparreboom Alex
机构信息
Department of Pharmaceutical Sciences, St Jude Children's Hospital, 332 North Lauderdale, DTRC, Mail Stop 313, Room I5308, Memphis, TN 38105, USA.
出版信息
Pharmacogenomics. 2009 Mar;10(3):339-44. doi: 10.2217/14622416.10.3.339.
Abstract
The solute carrier, human organic anion transporting polypeptide 1A2 (OATP1A2, OATP-A, OATP1 and OATP) is highly expressed in the intestine, kidney, cholangiocytes and the blood-brain barrier. This localization suggests that OATP1A2 may be vitally important in the absorption, distribution and excretion of a broad array of clinically important drugs. Several nonsynonymous polymorphisms have been identified in the gene encoding OATP1A2, SLCO1A2 (SLC21A3), with some of these variants demonstrating functional changes in the transport of OATP1A2 substrates.
摘要
溶质载体，人类有机阴离子转运多肽1A2（OATP1A2、OATP-A、OATP1和OATP）在肠道、肾脏、胆管细胞和血脑屏障中高度表达。这种定位表明OATP1A2在多种临床重要药物的吸收、分布和排泄中可能至关重要。在编码OATP1A2的基因SLCO1A2（SLC21A3）中已鉴定出几种非同义多态性，其中一些变体在OATP1A2底物的转运中表现出功能变化。
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