T淋巴细胞中丝氨酸/苏氨酸激酶调控与功能的新见解。
New insights into the regulation and function of serine/threonine kinases in T lymphocytes.
作者信息
Matthews Sharon A, Cantrell Doreen A
机构信息
Division of Medical Sciences, Centre for Oncology and Molecular Medicine, Ninewell's Hospital and Medical School, University of Dundee, Dundee, UK.
出版信息
Immunol Rev. 2009 Mar;228(1):241-52. doi: 10.1111/j.1600-065X.2008.00759.x.
Abstract
The development of T lymphocytes in the thymus and the function of mature T cells in adaptive immune responses are choreographed by antigen receptors, costimulatory molecules, adhesion molecules, cytokines, and chemokines. These extrinsic stimuli are coupled to a diverse network of signal transduction pathways that control the transcriptional and metabolic programs that determine T-cell function. At the core of T-lymphocyte signal transduction is the regulated metabolism of inositol phospholipids and the production of two key lipid second messengers: polyunsaturated diacylglycerols (DAGs) and phosphatidylinositol (3-5) triphosphate [PI-(3-5)-P(3)]. The object of the present review is to discuss facts, controversies, and unresolved issues about DAG and PI-(3,4,5)-P(3) production in T lymphocytes and to discuss some of the serine/threonine kinases that control unique aspects of T-lymphocyte biology and coordinate T-cell participation in adaptive immune responses.
摘要
胸腺中T淋巴细胞的发育以及成熟T细胞在适应性免疫反应中的功能，是由抗原受体、共刺激分子、黏附分子、细胞因子和趋化因子精心编排的。这些外在刺激与一个多样的信号转导通路网络相耦合，该网络控制着决定T细胞功能的转录和代谢程序。T淋巴细胞信号转导的核心是肌醇磷脂的调节代谢以及两种关键脂质第二信使的产生：多不饱和二酰基甘油（DAGs）和磷脂酰肌醇（3-5）三磷酸[PI-(3-5)-P(3)]。本综述的目的是讨论关于T淋巴细胞中DAG和PI-(3,4,5)-P(3)产生的事实、争议和未解决的问题，并讨论一些控制T淋巴细胞生物学独特方面并协调T细胞参与适应性免疫反应的丝氨酸/苏氨酸激酶。
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