Knobbe C B, Lapin V, Suzuki A, Mak T W
Campbell Family Institute for Breast Cancer Research, University of Toronto, 620 University Avenue, Toronto, Ontario, Canada.
Oncogene. 2008 Sep 18;27(41):5398-415. doi: 10.1038/onc.2008.238.
In 1997, PTEN (phosphatase and tensin homologue deleted on chromosome 10, 10q23.3) was identified as an important tumor suppressor gene that is inactivated in a wide variety of human cancers. Ever since, PTEN's function has been extensively studied, and huge progress has been made in understanding PTEN's role in normal physiology and disease. In this review, we will systematically summarize the important data that have been gained from gene inactivation studies in mice and will put these data into physiological context using a tissue-by-tissue approach. We will cover mice exhibiting complete and constitutive inactivation of Pten as well as a large number of strains in which Pten has been conditionally deleted in specific tissues. We hope to highlight not only the tumor suppressive function of Pten but also its roles in embryogenesis and in the maintenance of the normal physiological functions of many organ systems.
1997年，PTEN（第10号染色体缺失的磷酸酶及张力蛋白同源物，10q23.3）被鉴定为一种重要的肿瘤抑制基因，在多种人类癌症中失活。从那时起，PTEN的功能得到了广泛研究，在理解PTEN在正常生理和疾病中的作用方面取得了巨大进展。在这篇综述中，我们将系统地总结从小鼠基因失活研究中获得的重要数据，并将这些数据采用逐个组织的方法放入生理背景中。我们将涵盖表现出Pten完全和组成型失活的小鼠，以及大量在特定组织中条件性删除Pten的品系。我们希望不仅突出Pten的肿瘤抑制功能，还强调其在胚胎发育以及许多器官系统正常生理功能维持中的作用。
