Bianco V, Colombo A, Tassan Simonat P
Cattedra di Patologia Ostetrica Ginecologica, Università delgi Studi di Milano.
Ann Ostet Ginecol Med Perinat. 1991 Jan-Feb;112(1):54-60.
During a first one year period a random treatment for climacteric symptoms with "Estriol vaginal cream" vs "Trazodone and Estriol vaginal cream" and, after it and only in patients not complaining of dyspareunia, with "Trazodone" vs "Veralipride" has been conducted. After the first year all women complaining of dyspareunia were treated with Estriol vaginal cream. Eighty women were enrolled in the five treatment groups. After three months of treatment, a good remission of symptoms was shown, with differences in relations to treatment schedules. Dyspareunia subsided for more than 70% in women treated with Estriol vaginal cream (either by itself or in association), and Estriol vaginal cream achieved the best response from the highest number of the considered symptoms, besides being the only active treatment in insomnia. A good answer on hot flushes and "irritability, anxiety, depression" was obtained by Trazodone, while Veralipride showed to be more active on all neurovegetative symptoms (hot flushes, sweatings, tinglings, palpitations, astenia).
在第一个为期一年的阶段，针对更年期症状进行了随机治疗，比较了“雌三醇阴道乳膏”与“曲唑酮和雌三醇阴道乳膏”，并且在这之后，仅对未主诉性交困难的患者，比较了“曲唑酮”与“维拉必利”。在第一年之后，所有主诉性交困难的女性均接受雌三醇阴道乳膏治疗。80名女性被纳入五个治疗组。治疗三个月后，症状出现了良好的缓解，不同治疗方案之间存在差异。使用雌三醇阴道乳膏（单独使用或联合使用）治疗的女性中，超过70%的性交困难症状得到缓解，而且雌三醇阴道乳膏在被考虑的症状中，从最多数量的症状上取得了最佳反应，此外它还是治疗失眠的唯一有效疗法。曲唑酮对潮热和“易怒、焦虑、抑郁”有良好疗效，而维拉必利在所有植物神经症状（潮热、出汗、刺痛、心悸、乏力）方面表现得更为有效。
