与骨蜡或微原纤维胶原相比，微孔多糖微球不会抑制骨愈合。
Microporous polysaccharide hemospheres do not inhibit bone healing compared to bone wax or microfibrillar collagen.
作者信息
Ereth Mark, Sibonga Jean, Oliver William, Nuttall Gregory, Henderson Jennifer, Dekutoski Mark
机构信息
Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
出版信息
Orthopedics. 2008 Mar;31(3):222. doi: 10.3928/01477447-20080301-10.
Topical hemostats may reduce bone bleeding but the presence of residual matter may inhibit bone growth. We compared a recently approved hemostat, microporous polysaccharide hemospheres (Arista AH, Medafor Inc, Minneapolis, Minnesota), with conventional hemostatic agents in a rabbit calvarial model. Standard defects were created and microfibrillar collagen (Avitene; C.R. Bard Inc, Murray Hill, New Jersey), bonewax, or microporous polysaccharide hemospheres was applied. Bone growth was evaluated after fluorescent labeling the mineralization front. At 7 weeks bonewax and microfibrillar collagen had reduced bone growth compared to control or microporous polysaccharide hemospheres. Microporous polysaccharide hemospheres and control animals also had reduced rabbit calvarial defects compared to bonewax or microfibrillar collagen.
局部止血剂可能会减少骨出血，但残留物质的存在可能会抑制骨生长。我们在兔颅骨模型中，将一种最近获批的止血剂——微孔多糖微球（Arista AH，Medafor公司，明尼阿波利斯，明尼苏达州）与传统止血剂进行了比较。制造标准骨缺损后，应用微纤维胶原蛋白（Avitene；C.R. Bard公司，默里山，新泽西州）、骨蜡或微孔多糖微球。在对矿化前沿进行荧光标记后评估骨生长情况。7周时，与对照组或微孔多糖微球相比，骨蜡和微纤维胶原蛋白使骨生长减少。与骨蜡或微纤维胶原蛋白相比，微孔多糖微球组和对照组的兔颅骨缺损也减少。
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