Hartung H P, Reiners K, Schmidt B, Stoll G, Toyka K V
Department of Neurology, University of Würzburg, Federal Republic of Germany.
Ann Neurol. 1991 Jul;30(1):48-53. doi: 10.1002/ana.410300110.
Serum concentrations of the cytokine interleukin-2 (IL-2) were quantitated by enzyme-linked immunosorbent assay in 42 patients with Guillain-Barré syndrome, 15 patients with chronic idiopathic demyelinating polyradiculoneuropathy, 37 patients with other neuropathies, 54 patients with other noninflammatory, nondemyelinating neurological disorders, and 26 healthy control subjects. We found markedly increased serum levels of IL-2 in patients with Guillain-Barré syndrome and to a much lesser extent, in patients with chronic idiopathic demyelinating polyradiculoneuropathy. Increased serum concentrations of IL-2 in patients with Guillain-Barré syndrome returned to normal in parallel with recovery from the disease. These findings suggest ongoing T-cell proliferation in patients with Guillain-Barré syndrome and some patients with chronic idiopathic demyelinating polyradiculoneuropathy. IL-2 levels were also raised in patients with active multiple sclerosis, myasthenia gravis, and herpes simplex encephalitis, and some patients with polymyositis, invoking T cells in the pathogenesis of these diseases.
采用酶联免疫吸附测定法对42例吉兰-巴雷综合征患者、15例慢性特发性脱髓鞘性多发性神经根神经病患者、37例其他神经病患者、54例其他非炎性、非脱髓鞘性神经系统疾病患者以及26名健康对照者的细胞因子白细胞介素-2（IL-2）血清浓度进行了定量分析。我们发现，吉兰-巴雷综合征患者的血清IL-2水平显著升高，慢性特发性脱髓鞘性多发性神经根神经病患者的升高程度则小得多。吉兰-巴雷综合征患者血清IL-2浓度升高的情况随着疾病的恢复而恢复正常。这些发现提示，吉兰-巴雷综合征患者以及部分慢性特发性脱髓鞘性多发性神经根神经病患者存在持续的T细胞增殖。活动性多发性硬化症、重症肌无力和单纯疱疹性脑炎患者以及部分多发性肌炎患者的IL-2水平也升高，提示T细胞参与了这些疾病的发病机制。
