慢性炎症性脱髓鞘性多发性神经根神经病中的免疫反应与衰老。
The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy.
机构信息
Department of Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Departments of Clinical Neurosciences and Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 4N1, Canada.
出版信息
J Neuroinflammation. 2021 Mar 22;18(1):78. doi: 10.1186/s12974-021-02113-2.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) consists of various autoimmune subtypes in which the peripheral nervous system (PNS) is attacked. CIDP can follow a relapsing-remitting or progressive course where the resultant demyelination caused by immune cells (e.g., T cells, macrophages) and antibodies can lead to disability in patients. Importantly, the age of CIDP patients has a role in their symptomology and specific variants have been associated with differing ages of onset. Furthermore, older patients have a decreased frequency of functional recovery after CIDP insult. This may be related to perturbations in immune cell populations that could exacerbate the disease with increasing age. In the present review, the immune profile of typical CIDP will be discussed followed by inferences into the potential role of relevant aging immune cell populations. Atypical variants will also be briefly reviewed followed by an examination of the available studies on the immunology underlying them.
慢性炎症性脱髓鞘性多发性神经病（CIDP）由各种自身免疫亚型组成，其中外周神经系统（PNS）受到攻击。CIDP 可呈复发缓解或进行性病程，免疫细胞（如 T 细胞、巨噬细胞）和抗体引起的脱髓鞘可导致患者残疾。重要的是，CIDP 患者的年龄与其症状有关，特定亚型与不同的发病年龄有关。此外，老年患者在 CIDP 损伤后功能恢复的频率降低。这可能与免疫细胞群体的改变有关，随着年龄的增长，这些改变可能会使疾病恶化。在本综述中，将讨论典型 CIDP 的免疫特征，然后推断相关衰老免疫细胞群体的潜在作用。还将简要回顾非典型变异，并检查其潜在免疫学的现有研究。
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