聚醚离子载体和芳香脒对新生Hsd:(ICR)BR瑞士小鼠体内微小隐孢子虫的抑制作用
Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.
作者信息
Blagburn B L, Sundermann C A, Lindsay D S, Hall J E, Tidwell R R
机构信息
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849-5519.
出版信息
Antimicrob Agents Chemother. 1991 Jul;35(7):1520-3. doi: 10.1128/AAC.35.7.1520.
Abstract
Cryptosporidicidal effects of two polyether ionophores (maduramicin and alborixin), a fluorinated 4-quinolone (enrofloxacin), and three analogs of pentamidine were evaluated in a suckling mouse bioassay. Treatment with all compounds except enrofloxacin and one of the pentamidine analogs [1,3-di(4-imidazolinophenoxy)propane] resulted in significant (P less than 0.05) reductions in oocyst excretion.
摘要
在乳鼠生物测定中评估了两种聚醚离子载体（马杜霉素和阿伏里星）、一种氟化4-喹诺酮（恩诺沙星）以及三种喷他脒类似物的杀隐孢子虫效果。除恩诺沙星和一种喷他脒类似物[1,3-二(4-咪唑啉苯氧基)丙烷]外，用所有化合物处理均导致卵囊排泄显著减少（P小于0.05）。
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