Martin C, Lambert D, Bruguerolle B, Saux P, Freney J, Fleurette J, Meugnier H, Gouin F
Départment d'Anesthésie-Réanimation, Hôpital Sainte Marguerite, Marseille, France.
Antimicrob Agents Chemother. 1991 Aug;35(8):1582-5. doi: 10.1128/AAC.35.8.1582.
The pharmacokinetics of ofloxacin were studied in 12 intensive care patients, 6 of whom were under controlled mechanical ventilation. All patients had a creatinine clearance of greater than 80 ml/min per 1.73 m2. They were given 3 mg of ofloxacin per kg of body weight intravenously at a constant flow rate in 30 min twice a day for 7 days. Pharmacokinetic studies were performed on days 1 and 7. Between days 1 and 7, significant increases in the alpha (distribution) and beta (elimination) phase half-lives, the area under the serum concentration-time curve, and peak and trough levels in serum were observed, together with a marked decrease (greater than 50%) in total body clearance. Possible contributing factors for alteration of ofloxacin pharmacokinetics in ventilated patients were patient age, liver dysfunction, drug interaction, and drug accumulation in a deep compartment. This study shows that in intensive care patients the pharmacokinetics of ofloxacin differ from those reported for healthy volunteers.
对12例重症监护患者的氧氟沙星药代动力学进行了研究，其中6例接受机械通气控制。所有患者的肌酐清除率均大于每1.73平方米80毫升/分钟。他们每天两次，以恒定流速在30分钟内静脉注射每公斤体重3毫克氧氟沙星，共7天。在第1天和第7天进行药代动力学研究。在第1天至第7天之间，观察到α（分布）和β（消除）相半衰期、血清浓度-时间曲线下面积以及血清峰浓度和谷浓度显著增加，同时总体清除率显著降低（大于50%）。通气患者氧氟沙星药代动力学改变的可能影响因素包括患者年龄、肝功能不全、药物相互作用以及深部腔室中的药物蓄积。这项研究表明，在重症监护患者中，氧氟沙星的药代动力学与健康志愿者的报道不同。
