Martin C, Lambert D, Saux P, Meugnier H, Bruguerolle B, Freney J, Fleurette J, Gouin F
Département d'Anesthésie-Réanimation, Hôpital Sainte-Marguerite, Marseille.
Pathol Biol (Paris). 1990 Jun;38(5 ( Pt 2)):508-12.
The pharmacokinetics of ofloxacin was studied in 12 intensive care patients, 6 of whom being under mechanical ventilation. All patients had a creatinine clearance greater than 60 ml/min/1.73 m2 and they were given 3 mg/kg. IV ofloxacin within 30 mn, with a twice daily regimen for 7 days. Pharmacokinetic studies were performed on day 1 (D1) and 7 (D7). Between D1 and D7 a significant increase in T 1/2 beta, AUC and blood levels were observed together with a decrease in total body clearance. Creatinine clearance was not modified between D1 and D7 but ofloxacin renal clearance was considerably altered. Abnormalities in ofloxacin renal tubular secretion may account for the drug cumulation which was observed during repeated administration in intensive care patients.
在12名重症监护患者中研究了氧氟沙星的药代动力学，其中6名患者正在接受机械通气。所有患者的肌酐清除率均大于60 ml/min/1.73 m²，他们在30分钟内静脉注射3 mg/kg氧氟沙星，每天两次，共7天。在第1天（D1）和第7天（D7）进行了药代动力学研究。在D1和D7之间，观察到T 1/2β、AUC和血药浓度显著增加，同时总体清除率降低。D1和D7之间肌酐清除率未改变，但氧氟沙星的肾清除率发生了显著变化。氧氟沙星肾小管分泌异常可能是重症监护患者重复给药期间观察到药物蓄积的原因。
