Ayoub Albert E, Kostovic Ivica
Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Cereb Cortex. 2009 Aug;19(8):1705-7. doi: 10.1093/cercor/bhp025. Epub 2009 Mar 17.
Transitional neuronal layers are a hallmark of the prenatal and neonatal brain yet their contribution to the development of higher functions is not clear. Evidence accumulated over the last 3 decades shows that early connectivity and functional activity start in a transitional layer called the subplate zone (SPZ). The SPZ is host to a heterogeneous population of neurons and its evolutionary complexity peaked in the human brain. In this issue of Cerebral Cortex, three reports (Hoerder-Suabedissen et al., 2008; McKellar and Shatz, 2008; Moore et al., 2008) present new data and evidence in three species (mouse, rat, human) as to the function of the SPZ, to the heterogeneity of its cellular composition, and to the genetic basis of its development.
过渡性神经元层是产前和新生儿大脑的一个标志，但它们对高级功能发育的贡献尚不清楚。过去30年积累的证据表明，早期的连接性和功能活动始于一个称为板下层（SPZ）的过渡层。SPZ容纳了异质性的神经元群体，其进化复杂性在人类大脑中达到顶峰。在本期《大脑皮层》中，三篇报告（Hoerder-Suabedissen等人，2008年；McKellar和Shatz，2008年；Moore等人，2008年）提供了关于SPZ功能、其细胞组成的异质性以及其发育的遗传基础的新数据和证据，涉及三个物种（小鼠、大鼠、人类）。
