Demirag Mehmet Derya, Haznedaroglu Seminur, Sancak Banu, Konca Ceyla, Gulbahar Ozlem, Ozturk M Akif, Goker Berna
Section of Rheumatology, Gazi University School of Medicine, Ankara, Turkey.
Intern Med. 2009;48(6):421-6. doi: 10.2169/internalmedicine.48.1578. Epub 2009 Mar 16.
To investigate the role of circulating hepcidin, which is a homeostatic regulator of iron metabolism and a mediator of inflammation, in anemia associated with rheumatoid arthritis.
Forty patients with rheumatoid arthritis (19 with anemia and 21 without anemia), 12 patients with iron deficiency anemia and 14 healthy adults were studied. Serum hepcidin levels were analyzed with hepcidin prohormone solid phase enzyme-linked immunosorbent assay.
The mean serum hepcidin levels were significantly higher in patients with rheumatoid arthritis with anemia compared to healthy adults and those with iron deficiency anemia. The active rheumatoid arthritis group had significantly higher mean serum hepcidin levels than the inactive rheumatoid arthritis group. In the rheumatoid arthritis group, serum hepcidin levels were positively correlated with disease activity, but inversely correlated with hemoglobin levels. The serum hepcidin level was found to be a significant predictor for hemoglobin level.
Serum hepcidin levels are closely associated with disease activity in rheumatoid arthritis patients and might play a role in the pathobiology of chronic disease anemia associated with rheumatoid arthritis.
研究循环中的铁调素（一种铁代谢的稳态调节因子和炎症介质）在类风湿关节炎相关性贫血中的作用。
对40例类风湿关节炎患者（19例贫血患者和21例非贫血患者）、12例缺铁性贫血患者及14名健康成年人进行研究。采用铁调素前体固相酶联免疫吸附测定法分析血清铁调素水平。
与健康成年人及缺铁性贫血患者相比，类风湿关节炎贫血患者的血清铁调素平均水平显著更高。活动期类风湿关节炎组的血清铁调素平均水平显著高于非活动期类风湿关节炎组。在类风湿关节炎组中，血清铁调素水平与疾病活动度呈正相关，但与血红蛋白水平呈负相关。血清铁调素水平是血红蛋白水平的一个显著预测指标。
血清铁调素水平与类风湿关节炎患者的疾病活动度密切相关，可能在类风湿关节炎相关性慢性病贫血的病理生物学过程中发挥作用。
