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One-pot synthesis of cyclic antifreeze glycopeptides.

作者信息

Hachisu Masakazu, Hinou Hiroshi, Takamichi Manabu, Tsuda Sakae, Koshida Shuhei, Nishimura Shin-Ichiro

机构信息

Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, and Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo, Japan.

出版信息

Chem Commun (Camb). 2009 Apr 7(13):1641-3. doi: 10.1039/b815917c. Epub 2009 Feb 3.

Abstract

The first cyclic glycopeptides exhibiting significant antifreeze activity by forming hexagonal-bipyramidal ice crystals, denoted cyclic antifreeze glycopeptides (cyclic AFGPs), were constructed by a one-pot synthesis based on the controlled cyclization reaction of pre-formed small linear glycopeptides.

摘要

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