Lee Yan, Ishii Takehiko, Cabral Horacio, Kim Hyun Jin, Seo Ji-Hun, Nishiyama Nobuhiro, Oshima Hiroki, Osada Kensuke, Kataoka Kazunori
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Angew Chem Int Ed Engl. 2009;48(29):5309-12. doi: 10.1002/anie.200900064.
Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).
特别递送！开发了含有电荷转换部分柠康酰胺或顺乌头酰胺的聚离子复合物（PIC）胶束用于细胞质蛋白递送。蛋白质载物上电荷密度的增加有助于PIC胶束在无交联情况下的稳定性，并且内体中的电荷转换诱导PIC胶束解离，从而实现有效的内体释放（见图）。
