小儿泌尿生殖系统肿瘤
Pediatric genitourinary tumors.
作者信息
Castellino Sharon M, Martinez-Borges Anibal R, McLean Thomas W
机构信息
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
出版信息
Curr Opin Oncol. 2009 May;21(3):278-83. doi: 10.1097/CCO.0b013e328329f201.
PURPOSE OF REVIEW
We will review the 2007/2008 literature on pediatric genitourinary tumors.
RECENT FINDINGS
Newly identified constitutional epigenetic defects in Wilms tumor genes extend the understanding of Wilms tumor risk in children lacking syndromic features, and add to the complexity of the pathogenesis of these tumor suppressor genes. Pediatric renal cell carcinoma has distinct molecular characteristics and clinical associations from the adult counterpart. The pathway from PAX3-FKHR translocation to the development of rhabdomyosarcoma tumors has been further elucidated.
SUMMARY
Therapeutic strategies continue to be driven by developments in molecular diagnostics in pediatric genitourinary tumors.
综述目的
我们将回顾2007/2008年关于小儿泌尿生殖系统肿瘤的文献。
最新发现
在肾母细胞瘤基因中新发现的先天性表观遗传缺陷，扩展了我们对无综合征特征儿童肾母细胞瘤风险的理解，并增加了这些肿瘤抑制基因发病机制的复杂性。小儿肾细胞癌与成人肾细胞癌具有不同的分子特征和临床关联。从PAX3-FKHR易位到横纹肌肉瘤肿瘤发生的途径已得到进一步阐明。
总结
小儿泌尿生殖系统肿瘤的治疗策略继续由分子诊断的发展推动。
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