Planchard D, Domont J, Taranchon E, Monnet I, Tredaniel J, Caliandro R, Validire P, Besse B, Soria J-C, Fouret P
Medical Oncology and Translational Research, Institut de Cancérologie Gustave Roussy,Villejuif, France.
Ann Oncol. 2009 Jul;20(7):1257-63. doi: 10.1093/annonc/mdn785. Epub 2009 Mar 17.
The expression levels of excision repair cross-complementation group 1 (ERCC1), replication protein A (RPA) and xeroderma pigmentosum group F (XPF) nucleotide excision repair proteins may be important in the response to platin-based therapy in lung cancer patients. It is not known whether ERCC1, RPA and XPF expression levels differ between ever smokers (ES) and never smokers (NS).
ERCC1, RPA and XPF expression levels were immunohistochemically evaluated in 125 patients with resected lung adenocarcinoma (AC) and carefully reviewed smoking status.
ERCC1 was correlated with XPF (P = 0.001), but not with RPA (P = 0.11). In the univariate analysis, ERCC1 and XPF levels were higher in NS compared with ES (P = 0.004 and P = 0.003, respectively). In the multivariate analysis, the smoking status was predictive of the ERCC1 level [odds ratio (OR) 2.5, 95% confidence interval (CI) 1.03-6.2] after adjustment for variables linked to the smoking status, including age and the presence of bronchioloalveolar (BAC) features. The smoking status was also predictive of both RPA (OR 6.7, 95% CI 1.5-33.3) and XPF levels (OR 12.5, 95% CI 2.9-50) after adjusting for age, sex and BAC features.
In patients with resected lung AC, ERCC1, RPA and XPF expression levels are higher in NS compared with ES.
切除修复交叉互补基因1（ERCC1）、复制蛋白A（RPA）和着色性干皮病F组（XPF）核苷酸切除修复蛋白的表达水平可能在肺癌患者对铂类治疗的反应中起重要作用。目前尚不清楚曾经吸烟者（ES）和从不吸烟者（NS）之间ERCC1、RPA和XPF的表达水平是否存在差异。
对125例接受肺腺癌（AC）切除术的患者进行免疫组织化学评估ERCC1、RPA和XPF的表达水平，并仔细审查吸烟状况。
ERCC1与XPF相关（P = 0.001），但与RPA无关（P = 0.11）。在单因素分析中，NS组的ERCC1和XPF水平高于ES组（分别为P = 0.004和P = 0.003）。在多因素分析中，在调整与吸烟状况相关的变量（包括年龄和细支气管肺泡癌（BAC）特征）后，吸烟状况可预测ERCC1水平[比值比（OR）2.5，95%置信区间（CI）1.03 - 6.2]。在调整年龄、性别和BAC特征后，吸烟状况也可预测RPA（OR 6.7，95%CI 1.5 - 33.3）和XPF水平（OR 12.5，95%CI 2.9 - 50）。
在接受肺AC切除术的患者中，NS组的ERCC1、RPA和XPF表达水平高于ES组。
