代谢物结合核糖开关的结构与功能多样性。
The structural and functional diversity of metabolite-binding riboswitches.
作者信息
Roth Adam, Breaker Ronald R
机构信息
Howard Hughes Medical Institute, Yale University, New Haven, CT 06520-8103, USA.
出版信息
Annu Rev Biochem. 2009;78:305-34. doi: 10.1146/annurev.biochem.78.070507.135656.
Abstract
The cellular concentrations of certain metabolites are assiduously monitored to achieve appropriate levels of gene expression. Although proteins have long been known to act as sensors in this capacity, metabolite-binding RNAs, or riboswitches, also play an important role. More than 20 distinct classes of riboswitches have been identified to date, and insights to the molecular recognition strategies of a significant subset of these have been provided by detailed structural studies. This diverse set of metabolite-sensing RNAs is found to exploit a variety of distinct mechanisms to regulate genes that are fundamental to metabolism.
摘要
为了实现适当水平的基因表达，某些代谢物的细胞浓度受到严格监测。尽管长期以来人们都知道蛋白质在这种能力中可充当传感器，但代谢物结合RNA或核糖开关也发挥着重要作用。迄今为止，已鉴定出20多种不同类别的核糖开关，详细的结构研究为其中很大一部分的分子识别策略提供了见解。人们发现，这一多样的代谢物感应RNA集合利用多种不同机制来调控对新陈代谢至关重要的基因。
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