神经球蛋白的神经保护作用及机制
Neuroprotective roles and mechanisms of neuroglobin.
作者信息
Yu Zhanyang, Fan Xiang, Lo Eng H, Wang Xiaoying
机构信息
Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Neurol Res. 2009 Mar;31(2):122-7. doi: 10.1179/174313209X389866.
OBJECTIVE
The objectives of this work were to update and summarize recent experimental works on neuroglobin, mainly focus on its neuroprotective effects and the mechanisms.
METHODS
The literature was reviewed using PubMed database, and some of the recent findings from our laboratory were included.
RESULTS
Neuroglobin is a recently discovered tissue globin with a high affinity for oxygen and is widely and specifically expressed in neurons of vertebrate's central and peripheral nervous systems. Investigations in the past several years have advanced our knowledge on the functions and mechanisms of neuroglobin, but many issues remain unclear. Emerging reports have shown that overexpression of neuroglobin confers neuroprotection against neuronal hypoxia or ischemia-induced damage in cultured neurons and in cerebral ischemic animal models. Accumulating findings suggest several possible neuroprotective roles and mechanisms including ligand binding and oxygen sensing, modulation of cell signaling pathways and maintenance of mitochondria function.
CONCLUSION
Emerging experimental works suggest that neuroglobin is neuroprotective against hypoxic/ischemic insults, probably via ligand binding and oxygen sensing, modulation of cell signaling pathways and maintenance of mitochondria function.
目的
本研究的目的是更新和总结近期关于神经球蛋白的实验研究，主要聚焦于其神经保护作用及机制。
方法
使用PubMed数据库对文献进行综述，并纳入了我们实验室近期的一些研究发现。
结果
神经球蛋白是一种最近发现的对氧具有高亲和力的组织球蛋白，在脊椎动物中枢和外周神经系统的神经元中广泛且特异性表达。过去几年的研究增进了我们对神经球蛋白功能和机制的了解，但仍有许多问题尚不清楚。新出现的报道表明，在培养的神经元和脑缺血动物模型中，神经球蛋白的过表达可对神经元缺氧或缺血诱导的损伤起到神经保护作用。越来越多的研究结果提示了几种可能的神经保护作用和机制，包括配体结合与氧感应、细胞信号通路的调节以及线粒体功能的维持。
结论
新出现的实验研究表明，神经球蛋白可能通过配体结合与氧感应、细胞信号通路的调节以及线粒体功能的维持，对缺氧/缺血性损伤起到神经保护作用。
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