Sharma Radha, Gupta Pradeep K, Mazumder Avik, Dubey Devendra K, Ganesan Kumaran, Vijayaraghavan R
Defence Research and Development Establishment, Gwalior, India.
J Pharm Biomed Anal. 2009 May 1;49(4):1092-6. doi: 10.1016/j.jpba.2009.01.035. Epub 2009 Feb 6.
A rapid selective and accurate quantitative (1)H NMR method was developed for the simultaneous analysis of obidoxime chloride and atropine sulfate, the active components in parenteral injection devices (PID) used for the emergency treatment of poisoning by toxic organophosphates. The spectra were acquired in 90% H(2)O-10% D(2)O using sodium 3-(trimethylsilyl)-1-propane sulfonate hydrate as the internal standard. Both synthetic mixtures and dosage forms were assayed. The results were compared with those obtained from a reported HPLC method.
开发了一种快速、选择性且准确的定量（1）H NMR方法，用于同时分析氯解磷定和硫酸阿托品，这两种物质是用于急性有机磷中毒急救的注射用解毒药（PID）中的活性成分。使用3-（三甲基硅烷基）-1-丙烷磺酸钠水合物作为内标，在90% H₂O-10% D₂O中采集光谱。对合成混合物和剂型均进行了测定。将结果与报道的HPLC方法所获结果进行了比较。
