Matalliotakis Ioannis M, Cakmak Hakan, Krasonikolakis Georgios D, Dermitzaki Despina, Fragouli Yvoni, Vlastos Georges, Arici Aydin
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
Surg Oncol. 2010 Mar;19(1):33-7. doi: 10.1016/j.suronc.2009.02.012. Epub 2009 Mar 18.
Recent studies reported that endometriosis could behave as a neoplasmatic process. The purpose of this study is to investigate the family risk of ovarian, colon and prostate cancer in women with endometriosis.
A search of medical records at the Yale New Haven Hospital from 1996 to 2002 identified 348 women with endometriosis and 179 women without endometriosis. All the cases were diagnosed by laparoscopy. Demographic characteristics were evaluated in women with positive or negative family history of cancers in women with endometriosis.
The overall risk of patients with endometriosis and positive family history of cancers was 7.7 (95% confidence interval 3.8-15.7) (chi(2)=39.8, P<0.001). Significant excess was observed for ovarian cancer in first- and second-degree relatives (OR=10.5, 95% CI (2.5-44.2), chi(2)=14.3, P<0.001), colon cancer (OR=7.5, 95% CI (2.7-21.1), chi(2)=18.2, P<0.001) and prostate cancer (OR=4.5, 95% CI (14-15.3), chi(2)=6.1, P<0.001). We found similar results in first- and second-degree relatives with ovarian and colon cancer. Moreover, we found similar results regarding the demographic characteristics in women with positive family history of cancers and in women with negative history.
These data suggest a familial association of endometriosis with ovarian, colon and prostate cancers. This evidence could support the genetics and molecular similarities between endometriosis and cancer. Future studies will be important to determine a clear genetic link between endometriosis and cancer.
近期研究报告称，子宫内膜异位症可能表现为一种肿瘤形成过程。本研究的目的是调查子宫内膜异位症女性患卵巢癌、结肠癌和前列腺癌的家族风险。
检索耶鲁纽黑文医院1996年至2002年的医疗记录，确定了348例子宫内膜异位症女性和179例无子宫内膜异位症的女性。所有病例均通过腹腔镜检查确诊。对有或无癌症家族史的子宫内膜异位症女性的人口统计学特征进行了评估。
有癌症家族史的子宫内膜异位症患者的总体风险为7.7（95%置信区间3.8 - 15.7）（χ² = 39.8，P < 0.001）。在一级和二级亲属中，卵巢癌（比值比 = 10.5，95%置信区间（2.5 - 44.2），χ² = 14.3，P < 0.001）、结肠癌（比值比 = 7.5，95%置信区间（2.7 - 21.1），χ² = 18.2，P < 0.001）和前列腺癌（比值比 = 4.5，95%置信区间（1.4 - 15.3），χ² = 6.1，P < 0.001）的风险显著增加。我们在有卵巢癌和结肠癌家族史的一级和二级亲属中发现了类似结果。此外，我们在有癌症家族史的女性和无癌症家族史的女性的人口统计学特征方面也发现了类似结果。
这些数据表明子宫内膜异位症与卵巢癌、结肠癌和前列腺癌之间存在家族关联。这一证据可能支持子宫内膜异位症与癌症之间的遗传学和分子相似性。未来的研究对于确定子宫内膜异位症与癌症之间明确的遗传联系将非常重要。
