Matalliotakis Ioannis M, Cakmak Hakan, Mahutte Neal, Goumenou Anastasia G, Koumantakis Georgios, Arici Aydin
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA.
Surg Oncol. 2008 Dec;17(4):289-93. doi: 10.1016/j.suronc.2008.01.002. Epub 2008 May 5.
Few studies examining the association of endometriosis with the risk of breast cancer. Our goal was to investigate the familial risk of breast cancer in women with endometriosis.
Retrospective study.
University-based endometriosis referral center.
Three hundred fifty-two women with endometriosis and 180 infertile women without endometriosis were studied using laparoscopy between August 1996 and February 2002. The endometriosis group was further subdivided into a group of women with 94 positive and 268 negative family histories of breast cancer.
MAIN OUTCOME MEASURE(S): The overall risk of familial breast cancer among first- and second-degree relatives in patients with endometriosis and the association between potential risk factors was estimated by chi(2) and by crude adjusted odds ratios (95% CI).
Positive family history of breast cancer was detected in (26.7%) 94/352 of endometriosis group and in (5%) 9/180 of controls. The relative risk of women with endometriosis and positive family history of breast cancer was (OR=6.9 (95% CI, 3.4-14.1), chi(2)=34.6, P<0.001). Endometriosis was associated with the risk of first-degree relatives of breast cancer (OR=5.69 (95% CI, 2.4-13.3), P<0.001). Moreover, endometriosis was significantly associated with the risk of breast cancer in mothers (OR=6.3 (95% CI, 2.2-17.8), P<0.001) and in maternal aunts (OR=5.9 (95% CI, 1.3-72.9), P<0.001). The two groups are similar in age, race height, main complaints, age of menarche, cycle length, days of flow, estimated blood loss, stage of endometriosis and the presence of endometrioma.
CONCLUSION(S): This study found an elevated risk associated with family history of breast cancer among women with endometriosis. A familial clustering interaction with a familial history of breast cancer in women with endometriosis is possible, but should be investigated further.
很少有研究探讨子宫内膜异位症与乳腺癌风险之间的关联。我们的目标是调查子宫内膜异位症女性患乳腺癌的家族风险。
回顾性研究。
大学附属子宫内膜异位症转诊中心。
1996年8月至2002年2月期间，对352例子宫内膜异位症女性和180例无子宫内膜异位症的不孕女性进行了腹腔镜检查。子宫内膜异位症组进一步分为有94例乳腺癌家族史阳性和268例乳腺癌家族史阴性的女性组。
通过卡方检验以及粗调整优势比（95%可信区间）评估子宫内膜异位症患者一级和二级亲属中家族性乳腺癌的总体风险以及潜在风险因素之间的关联。
子宫内膜异位症组中94/352（26.7%）有乳腺癌家族史阳性，对照组中9/180（5%）有乳腺癌家族史阳性。子宫内膜异位症且有乳腺癌家族史阳性的女性的相对风险为（优势比=6.9（95%可信区间，3.4 - 14.1），卡方=34.6，P<0.001）。子宫内膜异位症与乳腺癌一级亲属的风险相关（优势比=5.69（95%可信区间，2.4 - 13.3），P<0.001）。此外，子宫内膜异位症与母亲患乳腺癌的风险显著相关（优势比=6.3（95%可信区间，2.2 - 17.8），P<0.001）以及与姨妈患乳腺癌的风险显著相关（优势比=5.9（95%可信区间，1.3 - 72.9），P<0.001）。两组在年龄、种族、身高、主要症状、初潮年龄、月经周期长度、经期天数、估计失血量、子宫内膜异位症分期和子宫内膜瘤的存在情况方面相似。
本研究发现子宫内膜异位症女性中与乳腺癌家族史相关的风险升高。子宫内膜异位症女性中乳腺癌家族史可能存在家族聚集性相互作用，但应进一步研究。
