Faraji Amir H, Wipf Peter
Center for Chemical Methodologies & Library Development and Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Bioorg Med Chem. 2009 Apr 15;17(8):2950-62. doi: 10.1016/j.bmc.2009.02.043. Epub 2009 Feb 26.
This review highlights the properties of nanoparticles used in targeted drug delivery, including delivery to cells as well as organelle targets, some of the known pharmacokinetic properties of nanoparticles, and their typical modifications to allow for therapeutic delivery. Nanoparticles exploit biological pathways to achieve payload delivery to cellular and intracellular targets, including transport past the blood-brain barrier. As illustrative examples of their utility, the evaluation of targeted nanoparticles in the treatment of cancers and diseases of the central nervous system, such as glioblastoma multiforme, neurovascular disorders, and neurodegenerative diseases, is discussed.
本综述重点介绍了用于靶向药物递送的纳米颗粒的特性，包括向细胞以及细胞器靶点的递送、纳米颗粒一些已知的药代动力学特性，以及它们为实现治疗性递送而进行的典型修饰。纳米颗粒利用生物途径将有效载荷递送至细胞和细胞内靶点，包括穿过血脑屏障的运输。作为其效用的示例，本文讨论了靶向纳米颗粒在治疗癌症和中枢神经系统疾病（如多形性胶质母细胞瘤、神经血管疾病和神经退行性疾病）中的评估。
