“能量饮料”消费对健康年轻成年人的血流动力学和心电图参数的影响。

Effect of "energy drink" consumption on hemodynamic and electrocardiographic parameters in healthy young adults.

机构信息

Wayne State University, Detroit, MI, USA.

出版信息

Ann Pharmacother. 2009 Apr;43(4):596-602. doi: 10.1345/aph.1L614. Epub 2009 Mar 18.

DOI:10.1345/aph.1L614

PMID:19299320

Abstract

BACKGROUND

Energy drinks are frequently purported to improve cognitive function and concentration. However, the cardiovascular effects of these drinks have not been adequately studied.

OBJECTIVE

To determine the cardiac effects of a commercially available, multicomponent energy drink in healthy volunteers.

METHODS

Fifteen healthy adults were included in this prospective study. Individuals who had chronic medical conditions, were on chronic medication, or were pregnant or breast-feeding were excluded. Subjects abstained from caffeine for 48 hours prior to and during the study. In the morning on Day 1 of the study, while subjects were in a fasted state, baseline blood pressure (BP), heart rate (HR), and electrocardiographic (ECG) parameters were measured. Participants then consumed 500 mL (2 cans) of an energy drink and measurements were repeated 30 minutes, 1 hour, 2 hours, 3 hours, and 4 hours later. Participants then drank 500 mL of energy drink daily for the next 5 days. Day 1 protocol was repeated on Day 7.

RESULTS

On Days 1 and 7, maximum mean systolic BP (SBP), HR, and QTc interval occurred at 4 hours. Maximum diastolic BP (DBP) occurred at 2 hours on Days 1 and 7. Within 4 hours of energy drink consumption, on Days 1 and 7, respectively, SBP increased by 7.9% (p = 0.006) and 9.6% (p < 0.001), HR increased by 7.8% (p = 0.009) and 11.0% (p < 0.001), and QTc interval increased by 2.4% (p = 0.368) and 5.0% (p = 0.052). DBP increased by 7.0% (p = 0.046) and 7.8% (p = 0.063) within 2 hours of energy drink consumption on Days 1 and 7, respectively.

CONCLUSIONS

Although no significant ECG changes were observed, HR increased 5-7 beats/min and SBP increased 10 mm Hg after energy drink consumption.

摘要

背景

能量饮料常被宣称能提高认知功能和注意力。然而，这些饮料对心血管的影响尚未得到充分研究。

目的

确定一种市售多成分能量饮料对健康志愿者的心脏影响。

方法

本前瞻性研究纳入了 15 名健康成年人。患有慢性疾病、正在服用慢性病药物或处于妊娠或哺乳期的个体被排除在外。在研究期间和研究前 48 小时，受试者禁止摄入咖啡因。在研究的第 1 天早上，当受试者处于空腹状态时，测量基线血压（BP）、心率（HR）和心电图（ECG）参数。参与者随后饮用 500 毫升（2 罐）能量饮料，30 分钟、1 小时、2 小时、3 小时和 4 小时后重复测量。然后，参与者在接下来的 5 天内每天饮用 500 毫升能量饮料。第 7 天重复第 1 天的方案。

结果

在第 1 天和第 7 天，最大平均收缩压（SBP）、HR 和 QTc 间期在第 4 小时出现。最大舒张压（DBP）在第 1 天和第 7 天的第 2 小时出现。在饮用能量饮料后的 4 小时内，第 1 天和第 7 天 SBP 分别增加了 7.9%（p = 0.006）和 9.6%（p < 0.001），HR 分别增加了 7.8%（p = 0.009）和 11.0%（p < 0.001），QTc 间期分别增加了 2.4%（p = 0.368）和 5.0%（p = 0.052）。在第 1 天和第 7 天，能量饮料饮用后 2 小时内 DBP 分别增加了 7.0%（p = 0.046）和 7.8%（p = 0.063）。