Department of Pediatric Cardiology and Pediatric Intensive Care, Hospital of the University of Munich, Ludwig Maximilians University Munich, 81377 Munich, Germany.
Cells. 2022 Jan 31;11(3):498. doi: 10.3390/cells11030498.
Beyond their effect on blood pressure, the effect of energy drinks on heart rate in children and teenagers has not been evaluated until now. Thus, this study aimed to investigate the acute cardiovascular effects of energy drinks in healthy children and teenagers. Twenty-six children and adolescents (mean age 14.49 years) received a commercially available energy drink (ED) and placebo on two consecutive days based on the maximum caffeine dosage as proposed by the European Food Safety Authority. Heart rhythm and electrocardiographic time intervals were assessed in a prospective, randomized, double-blind, placebo-controlled, crossover clinical study design. ED consumption resulted in a significantly increased number of supraventricular extrasystoles (SVES) compared to the placebo, whereas supraventricular tachycardia or malignant ventricular arrhythmias were not observed. The mean heart rate (HR) was significantly lower following consumption of EDs. In contrast, QTc intervals were not affected by EDs. Being the first of its kind, this trial demonstrates the cardiovascular and rhythmological effects of EDs in minors. Interestingly, EDs were associated with adverse effects on heart rhythm. Whether higher dosages or consumption in children with preexisting conditions may cause potentially harmful disorders was beyond the scope of this pilot study and remains to be determined in future trials. Trial Registration Number (DRKS-ID): DRKS00027580.
目前为止，除了对血压的影响，能量饮料对儿童和青少年心率的影响尚未得到评估。因此，本研究旨在调查能量饮料对健康儿童和青少年的急性心血管影响。26 名儿童和青少年（平均年龄 14.49 岁）连续两天接受了市售能量饮料（ED）和安慰剂，剂量基于欧洲食品安全局提出的最大咖啡因剂量。在一项前瞻性、随机、双盲、安慰剂对照、交叉临床试验设计中，评估了心律和心电图时间间隔。与安慰剂相比，ED 摄入后室上性期外收缩（SVES）的数量明显增加，而未观察到室上性心动过速或恶性室性心律失常。ED 摄入后平均心率（HR）显著降低。相反，ED 对 QTc 间期没有影响。作为同类研究中的首例，该试验证明了 ED 在未成年人中的心血管和节律作用。有趣的是，ED 与心律失常的不良影响有关。更高的剂量或在有潜在疾病的儿童中使用是否会导致潜在的有害疾病，超出了本试验的范围，有待进一步研究。试验注册号（DRKS-ID）：DRKS00027580。
